Tryptophan Metabolites, Cytokines, and Fatty Acid Binding Protein 2 in ME/CFSPatient selection - CCC Simonato, Dall’Acqua, Zilli, Sut, Tenconi, Gallo, Sfriso, Sartori, Cavallin, Fiocco, Cogo, Agostinis, Aldovini, Bruttomesso, Marcolongo, Comai, and Baritussio (Italy & U.S.) - 19 November 21 -- "Interestingly, patients with the start of the disease after infection showed lower levels of kynurenine (p = 0.034) than those not starting after an infection. Changes in tryptophan metabolites and increased IL-17A levels in ME/CFS could both be compatible with anomalies in the sphere of energy metabolism. Overall, clinical traits together with serum biomarkers related to inflammation, intestine function, and tryptophan metabolism deserve to be further considered for the development of personalized medicine strategies for ME/CFS."
Complement Component C1q as a Potential Diagnostic Tool for Subtyping Patient selection - CCC Castro-Marrero, Zacares, Almenar-Perez, Alegre-Martin and Oltra (Spain) - 15 September 21 -- "The results show three symptom-based clusters, classified as severe, moderate, and mild, presenting significant differences (p < 0.05) in five blood parameters. Unexpectedly the study also revealed high levels of circulating complement factor C1q in 107/250 (43%) of the participants, placing C1q as a key molecule to identify an ME/CFS subtype/subgroup with more apparent pain symptoms."
Hand grip strength and fatigability: correlation with clinical parameters and diagnostic suitability in ME/CFSPatient selection - CCC Jäkel, Kedor, Grabowski, Wittke, Thiel, Scherbakov, Doehner, Scheibenbogen & Freitag (Germany) - 19 April 21 -- "HGS measurement is a simple diagnostic tool to assess the severity of muscle fatigue in ME/CFS. Repeat HGS assessment further allows to objectively assess fatigability and impaired recovery. Advantages of HGS measurement are easy handling, low cost and the low risk of causing PEM. Thus, it can be implemented easily in both primary care and research as an objective outcome parameter in clinical studies and drug development."
Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in ME/CFS Patient selection - CCC Schreiner, Harrer, Scheibenbogen, Lamer, Schlosser, Naviaux and Prusty (Germany, USA) - 01 April 20
Evidence of altered cardiac autonomic regulation in ME/CFSPatient selection - CCC M.Nelson, J.Bahl, J.Buckley, R.Thomson & K.Davison (Australia) - 25 October 2019 "... Meta-analysis revealed significant differences between patients and controls in a number of parameters, including patients having: higher RHR, HRtilt, orthostatic HR response, and LF/HF ratio; and lower HRmax, HRthreshold, HFP and RMSSD. These differences suggest an altered regulation of HR in ME/CFS patients that is suggestive of reduced vagal and increased sympathetic modulation of heart rate. ... However, the results of this review suggest that there are quantifiable differences in autonomic HR regulation in ME/CFS patients, and future research in ME/CFS populations should therefore focus on determining if there are additional HR parameters which have diagnostic utility in this group."
HFP = high frequency power of heart rate variability, HRmax = maximal heart rate, HRmentaltask = heart rate during mental task, HRtilt = heart rate during head-up tilt testing, LF/HF = ratio between low frequency and high frequency power of heart rate variability analysis, RHR = resting heart rate, RMSSD = root mean of the sum of squares of beat to beat deviations
Note: Some studies use various labels (ME/CFS, CFS, CFS/ME) due to the inconsistent use of these labels worldwide. This list focuses on the research subjects used showing research is applicable to myalgic encephalomyelitis.
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