RESEARCH USING PATIENTS WHO FIT THE INTERNATIONAL CONSENSUS CRITERIA*
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Diffusion Tensor Imaging Reveals Neuronal Microstructural Changes in ME/CFS Thapaliya, Marshall-Gradisnik, Staines & Barnden (Australia) - ICC - "In this study, we evaluated [Diffusion Tensor Imaging] DTI parameters to investigate microstructural abnormalities in ME/CFS patients. We estimated DTI parameter in 25 ME/CFS patients who met Fukuda criteria (ME/CFS-Fukuda), 18 ME/CFS patients who met International Consensus Criteria (ICC) (ME/CFS-ICC) only and 26 healthy control (HC) subjects. ... Our study demonstrated that DTI parameters are sensitive to microstructural changes in ME/CFS-ICC and could potentially act as an imaging biomarker of abnormal pathophysiology in ME/CFS. The study also shows that strict case definitions are essential in investigation of the pathophysiology of ME/CFS." - 06 August 21
Evaluating Routine Blood Tests According to Clinical Symptoms and Diagnostic Criteria in Individuals with ME/CFS Baklund, Dammen, Moum, Kristiansen, Duarte, Castro-Marrero, Helland & Strand (Norway, Spain) - ICC & CCC - "Case criteria applied: The CCC were used as inclusion criteria when the patients initially were diagnosed by the clinicians. In the current study DSQ was applied for diagnostic classification based on different diagnostic criteria and this revealed that all the 149 patients fulfilled the Fukuda case definition, and 93.3% (n = 139) fulfilled the CCC, and 63.1% (n = 94) patients fulfilled the ICC criteria. ... Results of several routine blood tests of ME/CFS patients differed from those healthy controls. Our findings particularly highlight that decreased creatinine and CK levels may indicate greater muscle damage and metabolic disturbances in ME/CFS patients and is worthy of future studies. This is also true of results that may indicate a possible low-grade inflammation in ME/CFS patients." - 14 July 21
Elements of Suffering in ME/CFS: The Experience of Loss, Grief, Stigma, and Trauma in the Severely and Very Severely Affected Fennell, Dorr & George (USA) - ICC - "This review article examines the suffering of patients with ME/CFS through the lens of the Fennell Four-Phase Model of chronic illness. Using a systems approach, this phase framework illustrates the effects of suffering on the patient and can be utilized to help the clinician, patient, family, and caregivers understand and respond to the patient’s experiences. We highlight the constructs of severity, uncertainty, ambiguity, and chronicity and their role in the suffering endured by patients with ME/CFS." - 09 May 21 Even though this report uses ME/CFS, it applies to ME. ~ MEI
Deconditioning does not explain orthostatic intolerance in ME/CFS van Campen, Rowe & Visser (Netherlands, USA) - ICC & Fukuda - This study shows that in ME/CFS patients orthostatic intolerance is not caused by deconditioning as defined on cardiopulmonary exercise testing. An abnormal high decline in cerebral blood flow during orthostatic stress was present in all ME/CFS patients regardless of their %peak VO2 results on cardiopulmonary exercise testing. - 04 May 21
Skewing of the B cell receptor repertoire in ME/CFS Sato, Ono, Matsutani, Nakamura, Shin, Amano, Suzuki & Yamamura (Japan) - ICC, CCC & Fukuda - Conclusion: "... we revealed a biased usage of several IGHV genes in peripheral blood B cells from ME/CFS patients. Results of receiver operating characteristic (ROC) analysis further indicated a possibility of distinguishing patients from healthy controls, based on the skewed B cell repertoire." - 27 March 21
Open-label study with the monoamine stabilizer (-)-OSU6162 in ME/CFS Haghighi, Forsmark, Zachrisson, Carlsson, Nilsson, Carlsson, Schuit & Gottfries (Sweden, The Netherlands) - ICC & Fukuda - Conclusion: "(‐)‐OSU6162 is well tolerated in ME/CFS patients and shows promise as a novel treatment to mitigate fatigue and improve mood and health‐related quality of life in ME/CFS. Obviously, the present results need to be confirmed in future placebo‐controlled double‐blind trials." - 02 February 21
The Economic Impacts of ME/CFS in an Australian Cohort Close, Marshall-Gradisnik, Byrnes, Smith, Nghiem & Staines (Australia) - Conclusion: The economic impacts of ME/CFS in Australia are significant. Improved understanding of the illness pathology, diagnosis, and management, may reduce costs, improve patient prognosis and decrease the burden of ME/CFS in Australia. - 21 August 20
Review of case definitions for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) Lim & Son (Republic of Korea) - "...ME/CFS has been named differently (e.g., postviral fatigue syndrome, neurasthenia) depending on the perspectives of the researchers; likewise, diagnostic criteria or case definitions have also been changed accordingly." Conclusions: "In this review, we found three key factors that have affected ME/CFS case definitions: etiology, pathophysiology, and exclusionary disorders. These factors have impacted the specification of the main symptoms, required conditions, and range of inclusive and exclusive symptoms/disorders in the development of case definitions." - 29 July 20
Novel characterisation of mast cell phenotypes from peripheral blood mononuclear cells in CFS/ME patients Nguyen, Johnston, Chacko, Gibson, Cepon, Smith, Staines & Marshall-Gradisnik (Australia) - Conclusions: "This preliminary study investigates mast cell phenotypes from PBMCs in healthy controls. We report significant increase of naïve MCs in moderate and severe CFS/ME patients compared with healthy controls. Moreover, a significant increase in CD40 ligand and MHC-II receptors on differentiated mast cells in severe CFS/ME patients. Peripheral MCs may be present in CFS/ME pathology however, further investigation to determine their role is required."
Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with CFS Loebel, Grabowski, Heidecke, Bauer, Hanitsch, Wittke, Meisel, Reinke, Volk, Fluge, Mella & Scheibenbogen (Germany, Norway) Results: "We found significantly higher autoantibody levels against M3 and M4 AChR and β2 AdR in CFS patients compared to controls. Crossreactivity between all 5 M and β1 and β2 AdR but also between M and β receptor was seen in a substantial portion of CFS patients as shown for M4 in Fig. 1C. The highest correlation was found between M3 and M4 receptor antibodies (r = 0.87), the lowest for M1 and M4 receptor antibodies (r = 0.59)." - 19 September 15
Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in ME/CFS Patient selection - CCC Schreiner, Harrer, Scheibenbogen, Lamer, Schlosser, Naviaux and Prusty (Germany, USA) - 01 April 20
Note: Some studies use various labels (ME/CFS, CFS, CFS/ME) due to the inconsistent use of these labels worldwide. This list focuses on the research subjects used showing research is applicable to myalgic encephalomyelitis.
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