RESEARCH USING PATIENTS
WHO FIT THE
INTERNATIONAL CONSENSUS CRITERIA*

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2020

Altered Structural Brain Networks Related to Adrenergic/Muscarinic Receptor Autoantibodies in Chronic Fatigue Syndrome
Fujii, Sato, Kimura, Matsuda, Ota, Maikusa, Suzuki, Amano, Shin, Yamamura, Mori and Sato (Japan) - Conclusion: "Our findings suggest that β1 AdR‐Ab and β2 AdR‐Ab are potential markers of ME/CFS." - 01 July 20
Cognitive Function Declines Following Orthostatic Stress in Adults With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
van Campen, Rowe, Verheught and Visser (Netherlands & US) - Conclusion: "As measured by the N-back test, working memory remains impaired in adults with ME/CFS following a 30-min head-up tilt test." - 26 June 20
Epidemiological and Clinical Factors Associated With Post-Exertional Malaise Severity in Patients With Myalgic encephalomyelitis/chronic Fatigue Syndrome
Ghali, Richa, Lacout, Gury, Beucher, Homedan, Lavigne and Urbanski (France) - Conclusion: "We identified some epidemiological and clinical features, which were positively associated with PEM severity in subsets of ME/CFS patients. This could help improving disease management and patients' quality of life." - 22 June 20
Cerebral Blood Flow Is Reduced in Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients During Mild Orthostatic Stress Testing: An Exploratory Study at 20 Degrees of Head-Up Tilt Testing
van Campen, Rowe and Visser (Netherlands, USA) - Conclusions: "Using a less demanding 20 degree tilt test for 15 min in severe ME/CFS patients resulted in a mean CBF decline of 27%. This is comparable to the mean 26% decline previously noted in less severely affected patients studied during a 30-min 70 degree head-up tilt. These observations have implications for the evaluation and treatment of severely affected individuals with ME/CFS." - 13 June 20

A Unifying Hypothesis of the Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Recognitions from the finding of autoantibodies against ß2-adrenergic receptors
Wirth and Scheibenbogen (Germany) - This is a compilation of many studies. While studies in this report may have used various criteria, the only criteria cited is the ICC. - 01 April 20

2019


Elevated blood lactate in resting conditions correlate with post-exertional malaise severity in patients with ME/CFS
Ghali, Lacout, Ghali, Gury, Beucher, Lozac’h, Lavigne and Urbanski (France) -
11 December 19

Reduced glycolytic reserve in isolated natural killer cells from ME/CFS patients: A preliminary investigation
Nguyen, Staines, Johnston and Marshall-Gradisnik (Australia) - June 2019

Diagnostic sensitivity of 2-day cardiopulmonary exercise testing in ME/CFS
Nelson, Buckley, Thomson, Clark, Kwiatek and Davison (Australia) - 14 March 19

2018


Blood Volume Status in ME/CFS Correlates With the Presence or Absence of Orthostatic Symptoms: Preliminary Results
M.C. van Campen, Rowe and Visser (Netherlands/US) - 15 November 18

Transient Receptor Potential Ion Channels in the Etiology and Pathomechanism of CFS/ME
Staines, Du Preez, Cabanas, Balinas, Eaton, Passmore, Maksoud, Redmayne and Marshall-Gradisnik (Australia) - 22 May 18

The etiologic relation between disequilibrium and orthostatic intolerance in patients with ME (CFS)
Miwa and Inoue (Japan) - 26 March 18

2017


Novel characterisation of mast cell phenotypes from peripheral blood mononuclear cells in CFS/ME patients
Nguyen, Johnston, Chacko, Gibson, Cepon, Smith, Staines and Marshall-Gradisnik

2016


Autonomic correlations with MRI are abnormal in the brainstem vasomotor centre in CFS
Barndena, Kwiatekc, Croucha, Burnet and Del Fante 
 
A Preliminary Comparative Assessment of the Role of CD8+ T Cells in CFS/ME and MS
Brenu, Broadley, Nguyen, Johnston, Ramos, Staines and Marshall-Gradisnik 

Epidemiological characteristics of CFS/ME in Australian patients
Johnston, Staines and Marshall-Gradisnik

Dysregulation of Protein Kinase Gene Expression in NK Cells from CFS/ME Patients
Chacko, Staines, Johnston and Marshall-Gradisnik


2015


Pilot Study of Natural Killer Cells in CFS/ME and Multiple Sclerosis
Huth, Brenu, Ramos, Nguyen, Broadley, Staines and Marshall‐Gradisnik

A Preliminary Comparative Assessment of the Role of CD8+ T Cells in CFS/ME and Multiple Sclerosis
Brenu, Broadley, Nguyen, Johnston, Ramos, Staines and Marshall-Gradisnik

A Comparison of Cytokine Profiles of CFS/ME and Multiple Sclerosis Patients
Wong, Nguyen, Brenu, Broadley, Staines and Marshall-Gradisnik

Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome
Loebel, Grabowski, Heidecke, Bauer, Hanitsch, Wittke, Meisel, Reinke, Volk, Fluge, Mella and Scheibenbogen (Germany & Norway)  Results: "We found significantly higher autoantibody levels against M3 and M4 AChR and β2 AdR in CFS patients compared to controls. Crossreactivity between all 5 M and β1 and β2 AdR but also between M and β receptor was seen in a substantial portion of CFS patients as shown for M4 in Fig. 1C. The highest correlation was found between M3 and M4 receptor antibodies (r = 0.87), the lowest for M1 and M4 receptor antibodies (r = 0.59)." - 19 Sept 15

2014


Neuroinflammation in Patients with CFS/ME: An ¹¹C-(R)-PK11195 PET Study
Nakatomi, Mizuno, Wada, Tanaka, Tazawa, Onoe, Fukuda, Kawabe, Takahashi, Kataoka, Shiomi, Yamaguti, Inaba, Kuratsune and Watanabe (Japan) - 24 March 14

2013


Immune Abnormalities in Patients Meeting New Diagnostic Criteria for CFS/ME
Brenu, Johnston, Hardcastle, Huth, Fuller, Ramos, Staines and Marshall-Gradisnik (Australia) - 14 November 13

 
*Note:  Some studies included patients who fit additional criteria as well as ICC.

RESEARCH USING CCC AND/OR CITING THE ICC
Some studies cited additional criteria as well as ICC

2020

Intravenous Cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. An Open-Label Phase II Study   Patient selection - CCC 
Rekeland, Fosså, Lande, Ktoridou-Valen, Sørland, Holsen, Tronstad, Risa, Alme, Viken, Lie, Dahl, Mella and Fluge  (Norway) - 29 April 20

The effect of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) severity on cellular bioenergetic function   Patient selection - Fukuda & CCC
Thomas, Elson, Straasheim, Newton and Walker (UK/US) - 10 April 20

Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome   Patient selection - CCC
Schreiner, Harrer, Scheibenbogen, Lamer, Schlosser, Naviaux and Prusty (Germany/US) - 01 April 20

Assessing diagnostic value of microRNAs from peripheral blood mononuclear cells and extracellular vesicles in ME/CFS  Patient selection - Fukuda & CCC - severely ill
Almenar-Pérez, Sarría, Nathanson & Oltra (Spain & US) - 07 February 20

New! An Isolated Complex V Inefficiency and Dysregulated Mitochondrial Function in Immortalized Lymphocytes from ME/CFS Patients  Patient selection - CCC
Missailidis, Annesley, Allan, Sanislav, Lidbury, Lewis, and Fisher (Australia) - 06 Feb 20

Cell-Based Blood Biomarkers for ME/CFS   Patient selection - CCC
Missailidis, Sanislav, Allan, Annesley and Fisher (Australia) - 03 February 20

2019


Transient receptor potential melastatin 2 channels are overexpressed in ME/CFS patients   Patient selection - not stated
Balinas, Cabanas, Staines and Marshall-Gradisnik 

Abnormal blood lactate accumulation during repeated exercise testing in ME/CFS   Patient selection - CCC
Lien, Johansen, Veierød, Haslestad, Bøhn, Melsom, Kardel and Iversen

2018


Evaluation of four clinical laboratory parameters for the diagnosis of ME
Patient selection - CCC
De Meirleir, Mijatovic, Subramanian, Schlauch and Lombardi 

Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from CFS/ME patients   Patient selection - CCC
Cabanas, Muraki, Eaton, Balinas, Staines and Marshall-Gradisnik

Immunoadsorption to remove ß2 adrenergic receptor antibodies in CFS/ME  Patient selection - CCC
Scheibenbogen, Loebel, Freitag, Krueger, Bauer, Antelmann, Doehner, Scherbakov, Heidecke, Reinke, Volk and Grabowski 

2017


Exercise – induced changes in cerebrospinal fluid miRNAs in Gulf War Illness, Chronic Fatigue Syndrome and sedentary control subjects   Patient selection - 
Baraniuk and Shivapurkar 
 
Cytokine signature associated with disease severity in CFS patients   
Patient selection - 
Montoya, Holmes, Anderson, Maecker, Rosenberg-Hasson, Valencia, Chu, Younger, Tato and Davis 

2016


Impaired calcium mobilization in natural killer cells from CFS/ME patients is associated with transient receptor potential melastatin 3 ion channels   
Patient selection - 
Nguyen, Johnston, Clarke, Smith, Staines and Marshall-Gradisnik 
 
Extended B cell phenotype in patients with ME/CFS: a cross-sectional study
Patient selection - 
Mensah, Bansal, Berkovitz, Sharma, Reddy, Leandro and Cambridge

2015


Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in CFS patients   Patient selection - 
Armstrong, McGregor, Lewis, Butt and Gooley 
 
Characterisation of cell functions and receptors in CFS/ME   Patient selection - 
Hardcastle, Brenu, Johnston, Nguyen, Huth, Wong, Ramos, Staines and Marshall-Gradisnik

2014


Evidence in CFS for severity-dependent upregulation of prefrontal myelination that is independent of anxiety and depression   Patient selection - 
Barnden, Crouch, Kwiatek, Burnet and Del Fante 
 
Oxidative and Nitrosative Stress and Immune-Inflammatory Pathways in Patients with ME/CFS   Patient selection - 
Morris and Maes 
 
Mitochondrial dysfunctions in ME/CFS explained by activated immuno-inflammatory, oxidative and nitrosative stress pathways   Patient selection - 
Morris and Maes

2013


Discriminative Validity of Metabolic and Workload Measurements for identifying Individuals with CFS   Patient selection - 
Snell, Stevens, Davenport and Van Ness 

 
Note:  Some studies use various labels (ME/CFS, CFS, CFS/ME) due to the inconsistent use of these labels worldwide.  This list focuses on the research subjects used showing research is applicable to myalgic encephalomyelitis.