RESEARCH USING PATIENTS
WHO FIT THE
INTERNATIONAL CONSENSUS CRITERIA*
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2020
The Economic Impacts of ME/CFS in an Australian Cohort
Close, Marshall-Gradisnik, Byrnes, Smith, Nghiem and Stains (Australia) - Conclusion: The economic impacts of ME/CFS in Australia are significant. Improved understanding of the illness pathology, diagnosis, and management, may reduce costs, improve patient prognosis and decrease the burden of ME/CFS in Australia. - 21 August 20
Close, Marshall-Gradisnik, Byrnes, Smith, Nghiem and Stains (Australia) - Conclusion: The economic impacts of ME/CFS in Australia are significant. Improved understanding of the illness pathology, diagnosis, and management, may reduce costs, improve patient prognosis and decrease the burden of ME/CFS in Australia. - 21 August 20
Validation of the Severity of ME/CFS by Other Measures than History: Activity Bracelet, Cardiopulmonary Exercise Testing and a Validated Activity Questionnaire: SF-36
van Campen, Rowe and Visser (Netherlands, USA) - This study confirms the validity of the ICC severity grading. - 14 August 20
van Campen, Rowe and Visser (Netherlands, USA) - This study confirms the validity of the ICC severity grading. - 14 August 20
Review of case definitions for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
Lim and Son (Republic of Korea) - "...ME/CFS has been named differently (e.g., postviral fatigue syndrome, neurasthenia) depending on the perspectives of the researchers; likewise, diagnostic criteria or case definitions have also been changed accordingly." Conclusions: "In this review, we found three key factors that have affected ME/CFS case definitions: etiology, pathophysiology, and exclusionary disorders. These factors have impacted the specification of the main symptoms, required conditions, and range of inclusive and exclusive symptoms/disorders in the development of case definitions." - 29 July 20
Lim and Son (Republic of Korea) - "...ME/CFS has been named differently (e.g., postviral fatigue syndrome, neurasthenia) depending on the perspectives of the researchers; likewise, diagnostic criteria or case definitions have also been changed accordingly." Conclusions: "In this review, we found three key factors that have affected ME/CFS case definitions: etiology, pathophysiology, and exclusionary disorders. These factors have impacted the specification of the main symptoms, required conditions, and range of inclusive and exclusive symptoms/disorders in the development of case definitions." - 29 July 20
Altered Structural Brain Networks Related to Adrenergic/Muscarinic Receptor Autoantibodies in CFS
Fujii, Sato, Kimura, Matsuda, Ota, Maikusa, Suzuki, Amano, Shin, Yamamura, Mori and Sato (Japan) - Conclusion: "Our findings suggest that β1 AdR‐Ab and β2 AdR‐Ab are potential markers of ME/CFS." - 01 July 20
Fujii, Sato, Kimura, Matsuda, Ota, Maikusa, Suzuki, Amano, Shin, Yamamura, Mori and Sato (Japan) - Conclusion: "Our findings suggest that β1 AdR‐Ab and β2 AdR‐Ab are potential markers of ME/CFS." - 01 July 20
Cognitive Function Declines Following Orthostatic Stress in Adults With ME/CFS
van Campen, Rowe, Verheught and Visser (Netherlands & US) - Conclusion: "As measured by the N-back test, working memory remains impaired in adults with ME/CFS following a 30-min head-up tilt test." - 26 June 20
van Campen, Rowe, Verheught and Visser (Netherlands & US) - Conclusion: "As measured by the N-back test, working memory remains impaired in adults with ME/CFS following a 30-min head-up tilt test." - 26 June 20
Epidemiological and Clinical Factors Associated With Post-Exertional Malaise Severity in Patients With ME/CFS
Ghali, Richa, Lacout, Gury, Beucher, Homedan, Lavigne and Urbanski (France) - Conclusion: "We identified some epidemiological and clinical features, which were positively associated with PEM severity in subsets of ME/CFS patients. This could help improving disease management and patients' quality of life." - 22 June 20
Ghali, Richa, Lacout, Gury, Beucher, Homedan, Lavigne and Urbanski (France) - Conclusion: "We identified some epidemiological and clinical features, which were positively associated with PEM severity in subsets of ME/CFS patients. This could help improving disease management and patients' quality of life." - 22 June 20
Cerebral Blood Flow Is Reduced in Severe ME/CFS Patients During Mild Orthostatic Stress Testing: An Exploratory Study at 20 Degrees of Head-Up Tilt Testing
van Campen, Rowe and Visser (Netherlands, USA) - Conclusions: "Using a less demanding 20 degree tilt test for 15 min in severe ME/CFS patients resulted in a mean CBF decline of 27%. This is comparable to the mean 26% decline previously noted in less severely affected patients studied during a 30-min 70 degree head-up tilt. These observations have implications for the evaluation and treatment of severely affected individuals with ME/CFS." - 13 June 20
van Campen, Rowe and Visser (Netherlands, USA) - Conclusions: "Using a less demanding 20 degree tilt test for 15 min in severe ME/CFS patients resulted in a mean CBF decline of 27%. This is comparable to the mean 26% decline previously noted in less severely affected patients studied during a 30-min 70 degree head-up tilt. These observations have implications for the evaluation and treatment of severely affected individuals with ME/CFS." - 13 June 20
A Unifying Hypothesis of the Pathophysiology of ME/CFS: Recognitions from the finding of autoantibodies against ß2-adrenergic receptors
Wirth and Scheibenbogen (Germany) - This is a compilation of many studies. While studies in this report may have used various criteria, the only criteria cited is the ICC. - 01 April 20
2019
Elevated blood lactate in resting conditions correlate with post-exertional malaise severity in patients with ME/CFS
Ghali, Lacout, Ghali, Gury, Beucher, Lozac’h, Lavigne and Urbanski (France) -
11 December 19
Reduced glycolytic reserve in isolated natural killer cells from ME/CFS patients: A preliminary investigation
Nguyen, Staines, Johnston and Marshall-Gradisnik (Australia) - June 2019
Diagnostic sensitivity of 2-day cardiopulmonary exercise testing in ME/CFS
Nelson, Buckley, Thomson, Clark, Kwiatek and Davison (Australia) - 14 March 19
2018
Blood Volume Status in ME/CFS Correlates With the Presence or Absence of Orthostatic Symptoms: Preliminary Results
M.C. van Campen, Rowe and Visser (Netherlands/US) - 15 November 18
Transient Receptor Potential Ion Channels in the Etiology and Pathomechanism of CFS/ME
Staines, Du Preez, Cabanas, Balinas, Eaton, Passmore, Maksoud, Redmayne and Marshall-Gradisnik (Australia) - 22 May 18
The etiologic relation between disequilibrium and orthostatic intolerance in patients with ME (CFS)
Miwa and Inoue (Japan) - 26 March 18
2017
Novel characterisation of mast cell phenotypes from peripheral blood mononuclear cells in CFS/ME patients
Nguyen, Johnston, Chacko, Gibson, Cepon, Smith, Staines and Marshall-Gradisnik
2016
Autonomic correlations with MRI are abnormal in the brainstem vasomotor centre in CFS
Barndena, Kwiatekc, Croucha, Burnet and Del Fante
A Preliminary Comparative Assessment of the Role of CD8+ T Cells in CFS/ME and MS
Brenu, Broadley, Nguyen, Johnston, Ramos, Staines and Marshall-Gradisnik
Epidemiological characteristics of CFS/ME in Australian patients
Johnston, Staines and Marshall-Gradisnik
Dysregulation of Protein Kinase Gene Expression in NK Cells from CFS/ME Patients
Chacko, Staines, Johnston and Marshall-Gradisnik
2015
Pilot Study of Natural Killer Cells in CFS/ME and Multiple Sclerosis
Huth, Brenu, Ramos, Nguyen, Broadley, Staines and Marshall‐Gradisnik
A Preliminary Comparative Assessment of the Role of CD8+ T Cells in CFS/ME and Multiple Sclerosis
Brenu, Broadley, Nguyen, Johnston, Ramos, Staines and Marshall-Gradisnik
A Comparison of Cytokine Profiles of CFS/ME and Multiple Sclerosis Patients
Wong, Nguyen, Brenu, Broadley, Staines and Marshall-Gradisnik
Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with CFS
Loebel, Grabowski, Heidecke, Bauer, Hanitsch, Wittke, Meisel, Reinke, Volk, Fluge, Mella and Scheibenbogen (Germany & Norway) Results: "We found significantly higher autoantibody levels against M3 and M4 AChR and β2 AdR in CFS patients compared to controls. Crossreactivity between all 5 M and β1 and β2 AdR but also between M and β receptor was seen in a substantial portion of CFS patients as shown for M4 in Fig. 1C. The highest correlation was found between M3 and M4 receptor antibodies (r = 0.87), the lowest for M1 and M4 receptor antibodies (r = 0.59)." - 19 Sept 15
2014
Neuroinflammation in Patients with CFS/ME: An ¹¹C-(R)-PK11195 PET Study
Nakatomi, Mizuno, Wada, Tanaka, Tazawa, Onoe, Fukuda, Kawabe, Takahashi, Kataoka, Shiomi, Yamaguti, Inaba, Kuratsune and Watanabe (Japan) - 24 March 14
2013
Immune Abnormalities in Patients Meeting New Diagnostic Criteria for CFS/ME
Brenu, Johnston, Hardcastle, Huth, Fuller, Ramos, Staines and Marshall-Gradisnik (Australia) - 14 November 13
*Note: Some studies included patients who fit additional criteria as well as ICC.
RESEARCH USING CCC AND/OR CITING THE ICC
Some studies cited additional criteria as well as ICC
2020
A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction Patient selection - CCC
Sweetman, Kleffmann, Edgar, de Lange, Vallings and Tate (New Zealand) - 24 September 20
Sweetman, Kleffmann, Edgar, de Lange, Vallings and Tate (New Zealand) - 24 September 20
Intravenous Cyclophosphamide in ME/CFS. An Open-Label Phase II Study Patient selection - CCC
Rekeland, Fosså, Lande, Ktoridou-Valen, Sørland, Holsen, Tronstad, Risa, Alme, Viken, Lie, Dahl, Mella and Fluge (Norway) - 29 April 20
Rekeland, Fosså, Lande, Ktoridou-Valen, Sørland, Holsen, Tronstad, Risa, Alme, Viken, Lie, Dahl, Mella and Fluge (Norway) - 29 April 20
The effect of ME/CFS severity on cellular bioenergetic function
Patient selection - Fukuda & CCC
Thomas, Elson, Straasheim, Newton and Walker (UK/US) - 10 April 20
Patient selection - Fukuda & CCC
Thomas, Elson, Straasheim, Newton and Walker (UK/US) - 10 April 20
Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in ME/CFS
Patient selection - CCC
Schreiner, Harrer, Scheibenbogen, Lamer, Schlosser, Naviaux and Prusty (Germany/US) - 01 April 20
Patient selection - CCC
Schreiner, Harrer, Scheibenbogen, Lamer, Schlosser, Naviaux and Prusty (Germany/US) - 01 April 20
Assessing diagnostic value of microRNAs from peripheral blood mononuclear cells and extracellular vesicles in ME/CFS Patient selection - Fukuda & CCC - severely ill
Almenar-Pérez, Sarría, Nathanson & Oltra (Spain & US) - 07 February 20
Almenar-Pérez, Sarría, Nathanson & Oltra (Spain & US) - 07 February 20
An Isolated Complex V Inefficiency and Dysregulated Mitochondrial Function in Immortalized Lymphocytes from ME/CFS Patients Patient selection - CCC
Missailidis, Annesley, Allan, Sanislav, Lidbury, Lewis, and Fisher (Australia) - 06 Feb 20
Missailidis, Annesley, Allan, Sanislav, Lidbury, Lewis, and Fisher (Australia) - 06 Feb 20
Cell-Based Blood Biomarkers for ME/CFS Patient selection - CCC
Missailidis, Sanislav, Allan, Annesley and Fisher (Australia) - 03 February 20
Missailidis, Sanislav, Allan, Annesley and Fisher (Australia) - 03 February 20
2019
Transient receptor potential melastatin 2 channels are overexpressed in ME/CFS patients Patient selection - not stated
Balinas, Cabanas, Staines and Marshall-Gradisnik
Abnormal blood lactate accumulation during repeated exercise testing in ME/CFS Patient selection - CCC
Lien, Johansen, Veierød, Haslestad, Bøhn, Melsom, Kardel and Iversen
2018
Evaluation of four clinical laboratory parameters for the diagnosis of ME
Patient selection - CCC
De Meirleir, Mijatovic, Subramanian, Schlauch and Lombardi
Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from CFS/ME patients Patient selection - CCC
Cabanas, Muraki, Eaton, Balinas, Staines and Marshall-Gradisnik
Immunoadsorption to remove ß2 adrenergic receptor antibodies in CFS/ME Patient selection - CCC
Scheibenbogen, Loebel, Freitag, Krueger, Bauer, Antelmann, Doehner, Scherbakov, Heidecke, Reinke, Volk and Grabowski
2017
Exercise – induced changes in cerebrospinal fluid miRNAs in Gulf War Illness, CFS and sedentary control subjects Patient selection -
Baraniuk and Shivapurkar
Cytokine signature associated with disease severity in CFS patients
Patient selection -
Montoya, Holmes, Anderson, Maecker, Rosenberg-Hasson, Valencia, Chu, Younger, Tato and Davis
2016
Impaired calcium mobilization in natural killer cells from CFS/ME patients is associated with transient receptor potential melastatin 3 ion channels
Patient selection -
Nguyen, Johnston, Clarke, Smith, Staines and Marshall-Gradisnik
Extended B cell phenotype in patients with ME/CFS: a cross-sectional study
Patient selection -
Mensah, Bansal, Berkovitz, Sharma, Reddy, Leandro and Cambridge
2015
Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in CFS patients Patient selection -
Armstrong, McGregor, Lewis, Butt and Gooley
Characterisation of cell functions and receptors in CFS/ME Patient selection -
Hardcastle, Brenu, Johnston, Nguyen, Huth, Wong, Ramos, Staines and Marshall-Gradisnik
2014
Evidence in CFS for severity-dependent upregulation of prefrontal myelination that is independent of anxiety and depression Patient selection -
Barnden, Crouch, Kwiatek, Burnet and Del Fante
Oxidative and Nitrosative Stress and Immune-Inflammatory Pathways in Patients with ME/CFS Patient selection -
Morris and Maes
Mitochondrial dysfunctions in ME/CFS explained by activated immuno-inflammatory, oxidative and nitrosative stress pathways Patient selection -
Morris and Maes
2013
Discriminative Validity of Metabolic and Workload Measurements for identifying Individuals with CFS Patient selection -
Snell, Stevens, Davenport and Van Ness
